1. Open the Microsoft 365 admin center and go to UsersActive users.

  2. Select the user, and in the flyout that appears, click Mail.

  3. In the Email apps section, click Manage email apps.

  4. Verify the Authenticated SMTP setting: unchecked = disabled, checked = enabled.

  5. When you're finished, click Save changes.

https://learn.microsoft.com/en-us/exchange/clients-and-mobile-in-exchange-online/authenticated-client-smtp-submission#use-the-microsoft-365-admin-center-to-enable-or-disable-smtp-auth-on-specific-mailboxes